Betaliq Initiates Enrollment of Phase 2 Clinical Trial For The Treatment of Glaucoma or Ocular Hypertension

Betaliq Initiates Enrollment of Phase 2 Clinical Trial Investigating BTQ-1901-A, BTQ 1901 B and BTQ-1902 For The Treatment of Glaucoma or Ocular Hypertension

TAMPA, FL, UNITED STATES, April 20,2021 /EINPresswire.com/ — Betaliq, Inc., a clinical-stage ophthalmic company focused on developing therapies for the treatment of glaucoma, today announced enrollment of the first subject in their Phase 2 clinical trial. Betaliq’s pipeline consists of two preservative-free and water-free glaucoma drug candidates based on Novaliq GmbH’s EyeSol® technology. EyeSol is the worldwide first and only water-free technology for topical ophthalmology products. Two EyeSol based ophthalmic products are currently approved in Europe and Australia and two active INDs are in late-stage development in the United States.

This Phase 2 multicenter, double-masked, 12-week, parallel-group, dose-ranging study aims to evaluate the ocular and systemic safety and the efficacy of BTQ-1901 (0.5% [A] and 1% [B] concentrations) and BTQ 1902 ophthalmic suspensions compared to 0.5% timolol ophthalmic solution in adult patients with elevated intraocular pressure (IOP) due to primary open-angle glaucoma or ocular hypertension. The study is expected to randomize 240 subjects in clinical sites across the US. The primary analysis will compare IOP values at three time points after 2 weeks, 6 weeks and 12 weeks of treatment.

Barry Butler, President and CEO of Betaliq commented, “We are very excited to advance our products into the clinic. BTQ-1901 and BTQ-1902 are based on Novaliq’s EyeSol technology that offers important advantages over traditional eye drop technology, including a drop size approximately 25% of the size of water-based drops. This smaller drop size has the potential to result in less systemic absorption and fewer negative systemic side effects that can be caused by beta blockers. Other advantages of EyeSol include longer residence time on the eye, better penetration into the ocular tissues, and no need for toxic preservatives. I believe the advantages offered by the EyeSol platform will bring significant benefits to glaucoma patients.”

Glaucoma is the leading cause of irreversible blindness worldwide, with an estimated 80 million people currently affected by the condition. The US glaucoma market of more than 3.0 million diagnosed patients is expected to expand further due to an aging population1. Ophthalmic beta blockers are a sizeable and growing therapeutic option in this market. Source: (1) Bright Focus Foundation, https://www.brightfocus.org/glaucoma/article/glaucoma-facts-figures

ABOUT BETALIQ
Betaliq, Inc. is a collaboration between Novaliq, and BLP Management Group, LLC. Betaliq was formed to develop ophthalmic beta blockers using Novaliq’s patented EyeSol non water formulation technology.

EyeSol is the first and only water-free eye drop technology for ophthalmology products. The EyeSol technology offers important advantages over traditional eye drops, including a drop size approximately 1/4 of the size of water-based drops. This smaller drop size has the potential to result in less systemic absorption. Other advantages of EyeSol® include longer residence time on the eye, better penetration, and no need for toxic preservatives.
Betaliq is developing two beta blockers for the treatment of glaucoma. BTQ-1901 is an EyeSol based drug product of a potent selective beta blocker that has not previously been used to treat glaucoma. BTQ-1902 is an EyeSol-based drug product of timolol, the most commonly prescribed beta blocker.
Beta blockers are one of the most commonly prescribed classes of medicines to treat glaucoma. Beta blockers reduce IOP by blockade of sympathetic nerve endings in the ciliary epithelium causing a fall in aqueous humor production. Beta blockers are often prescribed in combination with other glaucoma medications. Betaliq, Inc. is incorporated in Delaware and based in Tampa, Florida. More on www.betaliq.com.

ABOUT NOVALIQ
Novaliq is a pharmaceutical company focusing on the development and commercialization of first- and best-in-class ocular therapeutics based on EyeSol®, the worldwide first water-free technology. Novaliq offers an industry-leading portfolio addressing today’s unmet medical needs of millions of patients with eye diseases. Novaliq is headquartered in Heidelberg, Germany and has an office in Cambridge, MA, USA. The long-term shareholder is dievini Hopp BioTech holding GmbH & Co. KG, an active investor in Life and Health Sciences companies. More on www.novaliq.com.

Betaliq,
Inc. Barry Butler
+1 813-766-9539
email us here

This press release can be viewed online at: https://www.einpresswire.com/article/538838134
EIN Presswire’s priority is source transparency. We do not allow opaque clients, and our editors try to be careful about weeding out false and misleading content. As a user, if you see something

we have missed, please do bring it to our attention. Your help is welcome. EIN Presswire, Everyone’s Internet News PresswireTM, tries to define some of the boundaries that are reasonable in today’s world. Please see our Editorial Guidelines for more information.
© 1995-2021 IPD Group, Inc. All Right Reserved.

Sonja Kroesser named Top 25 Women Leaders in Biotechnology of 2022

Heidelberg, Germany, and Cambridge, MA, USA, November 15, 2022 – Novaliq, a biopharmaceutical company focusing on first- and best-in-class ocular therapeutics based on the unique EyeSol® water-free technology, is proud to announce that today our own Sonja Kroesser, Vice President and Head of Preclinical and Clinical Development, was named as a Top 25 Women Leaders in Biotechnology of 2022 by the Healthcare Technology Report.

Novaliq announces FDA acceptance of the new drug application for CyclaSol® for the treatment of dry eye disease

• PDUFA target action date is June 8, 2023

HEIDELBERG, Germany, and CAMBRIDGE, MA, USA, October 24, 2022 – Novaliq, a biopharmaceutical company focusing on first- and best-in-class ocular therapeutics based on the unique EyeSol® water-free technology, today announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for CyclASol® (cyclosporine ophthalmic solution), a first-of-its-kind anti-inflammatory product for the treatment for the signs and symptoms of dry eye disease (DED).

FDA accepts NDA filing for NOV03

VAUGHAN, Ontario, and HEIDELBERG, Germany, Sept. 6, 2022 – Bausch + Lomb Corporation (NYSE/TSX: BLCO) (“Bausch + Lomb”), a leading global eye health company dedicated to helping people see better to live better, and Novaliq GmbH, a biopharmaceutical company focusing on first- and best-in-class ocular therapeutics, today announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) filing for investigational treatment NOV03 (perfluorohexyloctane). A potential first-in-class eye drop with a novel mechanism of action, NOV03 is an investigational therapy to treat the signs and symptoms of dry eye disease (DED) associated with Meibomian gland dysfunction (MGD). NOV03 has been assigned a Prescription Drug User Fee Act (PDUFA) action date of June 28, 2023.

Dermaliq Therapeutics Announces First Patient Dosed in Phase 1b/2 Trial Evaluating DLQ02 for Treatment of Plaque Psoriasis

Wilmington, Delaware, August 18, 2022 – Dermaliq Therapeutics, Inc. (Dermaliq), a private, clinical stage pharmaceutical company with a focus on dermatology, today announced first patient dosed in a Phase 1b/2a trial with DLQ02, a topical calcineurin inhibitor. The trial is designed to evaluate the safety, systemic absorption, pharmacodynamics, and clinical efficacy of DLQ02 in patients with plaque psoriasis.

Novaliq submits New Drug Application seeking approval for first-of-a-kind Dry Eye Disease Treatment CyclASol®

Heidelberg, Germany, and Cambridge, MA, USA, August 09, 2022 – Novaliq, a biopharmaceutical company focusing on first- and best-in-class ocular therapeutics based on the unique EyeSol® water-free technology, today announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) seeking approval for CyclASol® (cyclosporine ophthalmic solution), a proposed novel treatment for the signs and symptoms of dry eye disease (DED).